The official Binding of Isaac multiplayer card game, about sacrifice, betrayal and hoarding.
2-4 players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. The first player to end their turn with 4 souls is the winner. Cooperation, barter, and betrayal is encouraged.
This game is for ages 13 and up, and takes between 30-60 minutes to play.